Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

Investigation of signal integration by non-catalytic tyrosine phosphorylated receptors in leukocytes (360G-Wellcome-099812_Z_12_Z)

This work will investigate signal integration in cells through analysis of non-catalytic tyrosine-phosphorylated receptors (NTRs). NTRs are a recently described group of leukocyte cell-surface receptors [1, 2] that share a numberof features, including: i) they contain, or associate with adaptor molecules that contain, tyrosine residues that are phosphorylated by extrinsic kinases such as Lck; ii) they have relatively small extracellular domains (<20nm); iii) they bind surface-associated ligands. I will focus on analysis of interactions between NTRs containing immunoreceptor tyrosine-based activating motifs (ITAMs) and those containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Key goals of the research include: 1) To develop a system for analysis of signal integration at the cell surface 2) To determine whether matched sizes of receptor/ligand pairs are required for signal integration of ITIM- and ITAM-containing receptors 3) To determine the importance of the length of the intracellular tail of ITIM-containing NTRs for inhibitory efficiency

£159,340

25 Jun 2012

Grant details
Amount Awarded 159340
Applicant Surname Paterson
Approval Committee PhD Studentships
Award Date 2012-06-25T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title PhD Studentship (Basic)
Internal ID 099812/Z/12/Z
Lead Applicant Ms Rachel Paterson
Planned Dates: End Date 2016-12-31T00:00:00+00:00
Planned Dates: Start Date 2012-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Keith Gull
Additional data added by GrantNav