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Developing a novel single dose prime-boost vaccine against malaria (360G-Wellcome-099813_Z_12_Z)

The main goal of this project is to develop a new vaccine delivery platform for a single dose prime-boost immunisation regime that would be applicable to current and future vaccines requiring a prime-boost approach. This novel platform is based on the technological advance of the production ofmicrocapsules from biodegradable polymers, which can act as vehicles into which the vaccine can be incorporated and then subsequently released in a delayed time fashion. After achieving the optimal conditions for the microcapsules and the encapsulated vaccine, the aim is to mix the unencapsulated vaccine with the encapsulated booster vaccine dose and then administer both as a single injection. The new methodology will be tested with our current candidate malaria vaccine regime of heterologous immunisation using different viral vectors as a proof of concept. Using this approach, the vaccine delivery efficiency would be optimised by reducing the number of doses required from multiple into a single dose immunisation regime. Reducing the number of repeated injections would mean reduced costs, fewer clinic visits and a higher compliance rate among vaccinees. A successful single dose formulation could provide strong evidence for the initiation of clinical trials of the new technology with considerable benefitsfor future vaccine development


25 Jun 2012

Grant details
Amount Awarded 159340
Applicant Surname Krastev
Approval Committee PhD Studentships
Award Date 2012-06-25T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title PhD Studentship (Basic)
Internal ID 099813/Z/12/Z
Lead Applicant Mr Christos Krastev
Planned Dates: End Date 2017-04-30T00:00:00+00:00
Planned Dates: Start Date 2012-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Keith Gull
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