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Role of interleukin 33 in intestinal homeostasis (360G-Wellcome-099814_Z_12_Z)

This research project will focus on the identification of the role of interleukin 33 (IL-33) in intestinal homeostasis. IL-33 belongs to the IL-1 family and has been shown to mediate both pro-inflammatory and anti-inflammatory processes depending on the disease context. Although IL-33 is produced in high amounts in the intestine little is known about its role ininflammatory bowel disease (IBD) development and progression. In this project I will use in vitro and in vivo systems, including knock-out and reporter mouse strains, in order to describe IL-33 signalling in the gut. Recent studies suggest that intestinal regulatory T cells (Tregs) express high levelsof IL-33R and that this pathway contributes to their function. I will build onthese studies to identify key downstream pathways activated by IL-33 in Treg cells that promote their function and how these are regulated by pro-inflamamtory mediators. Altogether the results of this study may lead to identification of potential novel therapeutic targets in IBD.

£159,340

25 Jun 2012

Grant details
Amount Awarded 159340
Applicant Surname Chomka
Approval Committee PhD Studentships
Award Date 2012-06-25T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title PhD Studentship (Basic)
Internal ID 099814/Z/12/Z
Lead Applicant Ms Agnieszka Chomka
Planned Dates: End Date 2016-12-31T00:00:00+00:00
Planned Dates: Start Date 2012-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Keith Gull
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