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Role of interleukin 33 in intestinal homeostasis (360G-Wellcome-099814_Z_12_Z)

This research project will focus on the identification of the role of interleukin 33 (IL-33) in intestinal homeostasis. IL-33 belongs to the IL-1 family and has been shown to mediate both pro-inflammatory and anti-inflammatory processes depending on the disease context. Although IL-33 is produced in high amounts in the intestine little is known about its role ininflammatory bowel disease (IBD) development and progression. In this project I will use in vitro and in vivo systems, including knock-out and reporter mouse strains, in order to describe IL-33 signalling in the gut. Recent studies suggest that intestinal regulatory T cells (Tregs) express high levelsof IL-33R and that this pathway contributes to their function. I will build onthese studies to identify key downstream pathways activated by IL-33 in Treg cells that promote their function and how these are regulated by pro-inflamamtory mediators. Altogether the results of this study may lead to identification of potential novel therapeutic targets in IBD.


25 Jun 2012

Grant details
Amount Awarded 159340
Applicant Surname Chomka
Approval Committee PhD Studentships
Award Date 2012-06-25T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title PhD Studentship (Basic)
Internal ID 099814/Z/12/Z
Lead Applicant Ms Agnieszka Chomka
Planned Dates: End Date 2016-12-31T00:00:00+00:00
Planned Dates: Start Date 2012-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Keith Gull
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