Institute of Metabolic Science. (360G-Wellcome-100574_B_12_Z)

With support from the Wellcome Trust and MRC, we have established an internationally leading Institute for Metabolic Science (IMS) in Cambridge. The world-class investigators we have assembled, combined with the excellent facilities we have established, have brought us within sight of our goal to translate advances in the understanding of basic mechanisms involved in obesity, diabetes and related metabolic diseases into benefits for health. In this proposal, we seek support for: 1. The co nstruction of a dedicated Metabolic Clinical Research Facility (MCRF) and Eating Behaviour Unit (EBU) to support the expansion of translational research programmes and capitalise on local strengths in the basic and clinical neuroscience of appetitive behaviour. 2. A collaborative programme with the Wellcome Trust Sanger Institute in the generation and phenotyping of murine models of metabolic disease. 3. Improved cell imaging and proteomic facilities in collaboration with the Cambridge Ins titute for Medical Research (CIMR). 4. Equipment to update our core Genomics/Transcriptomics laboratory We have been encouraged to submit a complementary bid to the MRC and further support is being provided by the University of Cambridge. If awarded, these additional resources will significantly enhance our abilities to conduct the highest level basic and translational science in metabolism.