Wellcome Trust PhD Programme in Mathematical Genomics and Medicine. (360G-Wellcome-102274_Z_13_Z)
Myc is a key oncogene in many cancers occurring across a diverse range of tissues. tn order to better understand and trea t such cancers, it is vital that we understand how the opposing functions of Myc, proliferation and apoptosis, are balanced and regulated in healthy ti'ssue, and how this goes wrong in cancer. The aim of this research project is to build a comprehensive executable model of the Myc tra nscri ptiona I program in fibroblasts. Analysis of this executable netv;ork model could help identify unknown interactions between genes in the network.Furthermore, it may help find key regulators of Myc function, which could act as potential drug targets. Predictions gained from the modelling work will be validated experimentally in collaboration with the Evan lab at the Department of Biochemistry.
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Grant Details
| Amount Awarded | 159401 |
| Applicant Surname | Clarke |
| Approval Committee | PhD Studentships |
| Award Date | 2013-06-24T00:00:00+00:00 |
| Financial Year | 2012/13 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 102274/Z/13/Z |
| Lead Applicant | Mr Matthew Clarke |
| Partnership Value | 159401 |
| Planned Dates: End Date | 2017-12-20T00:00:00+00:00 |
| Planned Dates: Start Date | 2013-10-08T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |
| Sponsor(s) | Prof Simon Tavaré |