Long term outcomes of acute kidney injury - Establishing prognosis to design optimal management. (360G-Wellcome-102729_Z_13_Z)

Acute Kidney Injury (AKI) is common, affecting up to 20% of unscheduled hospital admissions. It is associated with poor patient outcomes; high mortality, protracted hospital length of stay and significant morbidity. There is wide variation in clinical practice and associated outcomes. It is expensive and represents a major burden on global healthcare. For those that recover to discharge from hospital the long-term is uncertain with increased mortality and subsequent risk of progressive loss of renal function leading to renal replacement therapy. There is a substantial gap in our knowledge of what factors and interventions affect both short and long term outcomes. Consequently current guidance lacks clarity, clinical applicability and has a poor evidence base. This fellowship focuses on investigating the factors influencing long-term outcomes after AKI. It aims to improve care through the development of prediction tools that will guide optimum practice and support healthcare planning. The proposal utilises two large population-based cohorts established in 2003. Novel data linkage to a central laboratory system together with access to routine administrative healthcare information and specialist registry data will enable detailed characterisation of patients and outcomes. With this information we will develop risk stratification models relevant to clinical practice.