Stratified medicine in Type 2 diabetes: Insights from the study of drug response. (360G-Wellcome-102820_Z_13_Z)
1. What are the clinical, biochemical and genomic characteristics associated with variation in glycaemic and non-glycaemic (e.g. weight change; lipid change) effects of diabetes drugs? 2. What are the mechanisms for variation in response and adverse reaction to diabetes drugs? I propose to address these research questions by harnessing outstanding pharmacoepidemiology and pharmacogenomics population resources that I have helped to create. I will use my experience in clinical physiology t o perform detailed metabolic phenotyping of patients selected by extreme phenotype or by genotype or biomarker.
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Grant Details
| Amount Awarded | 1795764 |
| Applicant Surname | Pearson |
| Approval Committee | Science Interview Panel |
| Award Date | 2013-12-03T00:00:00+00:00 |
| Financial Year | 2013/14 |
| Grant Programme: Title | Investigator Award in Science |
| Internal ID | 102820/Z/13/Z |
| Lead Applicant | Prof Ewan Pearson |
| Partnership Value | 1795764 |
| Planned Dates: End Date | 2021-08-15T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-02-16T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |