CALR mutations and human myeloproliferative neoplasms. (360G-Wellcome-104710_Z_14_Z)
This application combines studies of patient samples with mouse and cell line models to address two questions: 1) How do CALR mutations influence haematopoietic stem cell (HSC) biology, megakaryopoiesis and myeloproliferative neoplasm (MPN) pathogenesis? 2) What are the consequences of CALR mutations for cytokine signaling and CALR function? These are relevant to two of the Wellcome Trust's Research Challenges - genetics/genomics and aging/chronic disease.
Where is this data from?
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Grant Details
| Amount Awarded | 2000004 |
| Applicant Surname | Green |
| Approval Committee | Science Interview Panel |
| Award Date | 2014-07-08T00:00:00+00:00 |
| Financial Year | 2013/14 |
| Grant Programme: Title | Investigator Award in Science |
| Internal ID | 104710/Z/14/Z |
| Lead Applicant | Prof Tony Green |
| Partnership Value | 2000004 |
| Planned Dates: End Date | 2022-01-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-08-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |