CALR mutations and human myeloproliferative neoplasms. (360G-Wellcome-104710_Z_14_Z)
Myeloproliferative neoplasms are pre-leukaemic diseases in which abnormal bone marrow stem cells produce too many mature blood cells. These disorders are associated with increased thrombosis and the development of overt leukaemia. We have recently shown that many myeloproliferative neoplasm patients develop a mutation in the CALR gene. However CALR has not previously been linked to any malignancy and the molecular consequences of these mutations are completely unclear. This award will allow us to study how such mutations perturb normal blood cell formation and give rise to a myeloproliferative neoplasm.
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Grant Details
| Amount Awarded | 2000004 |
| Applicant Surname | Green |
| Approval Committee | Science Interview Panel |
| Award Date | 2014-07-08T00:00:00+00:00 |
| Financial Year | 2013/14 |
| Grant Programme: Title | Investigator Award in Science |
| Has the grant transferred? | No |
| Internal ID | 104710/Z/14/Z |
| Lead Applicant | Prof Tony Richard Green |
| Planned Dates: End Date | 2022-01-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-08-01T00:00:00+00:00 |
| Recipient Org: City | Cambridge |
| Recipient Org: Country | United Kingdom |
| Region | East of England |
| Research conducted at multiple locations? | No |
| Total amount including partnership funding | 2000004 |