How pathogenic cytosol-dwelling bacteria escape from autophagy. (360G-Wellcome-104752_Z_14_Z)

£959,957

Bacteria that invade the host cytosol encounter anti-microbial defenses distinct from those protecting other compartments such as the lumen of intracellular vesicles or the extracellular environment. Professional cytosol-dwelling bacteria therefore require specific adaptations to antagonize cytosolic defenses. Over the last years autophagy has emerged as the major cell-autonomous anti-bacterial defense system for the host cytosol (ref 1-3). Eat-me signals that label bacteria as cargo for au tophagy as well as the cargo receptors that direct such bacteria for autophagy have been identified. However, the weakest points in this defense system, as defined by successful bacterial countermeasures, remain largely to be discovered (ref 4-6). To improve our understanding of anti-bacterial autophagy and to develop novel strategies against professional cytosol-dwelling bacterial pathogens I propose to address the following questions: 1) How do professional cytosol-dwelling bacteria escape from autophagy? 2) Can we artificially enforce anti-bacterial autophagy against professional cytosol-dwellers? 3) Which additional cell-autonomous defenses are deployed in activated cells to detect, label and destroy professional cytosol-dwelling bacteria?

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Grant Details

Amount Awarded 959957
Applicant Surname Randow
Approval Committee Science Interview Panel
Award Date 2014-07-08T00:00:00+00:00
Financial Year 2013/14
Grant Programme: Title Investigator Award in Science
Internal ID 104752/Z/14/Z
Lead Applicant Dr Felix Randow
Partnership Value 959957
Planned Dates: End Date 2021-06-30T00:00:00+00:00
Planned Dates: Start Date 2015-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South West