Investigation of Viral Transmission Events based on Within-Host Time-Series Data (360G-Wellcome-105365_Z_14_Z)
The main aim of my research is to develop new techniques for investigating transmission events in influenza A virus. These techniques will be mathematical and computational in nature and revolve around the use of publicly available time-resolved within-host data. Specifically, I propose to use maximum likelihood methods to extract information on transmission bottleneck size and selection based on the time-evolution of genetic variants. As a secondary aim, I wish to extend my methods (and perhaps those of other authors) to allow for analysis of other viral species such as HIV, norovirus and picornavirus (foot-and-mouth disease). Influenza virus is particularly convenient to work with as it has a short lifetime, large population size and lacks homologous recombination, however, other RNA viruses are more complicated in these aspects. As a result of this, my initial algorithm may require important adjustments to reflect this. Key goals: ? Incorporation of genetic selection to my model developed during research rotation ? Implementation of Gaussian transmission step in maximum likelihood approach leading to a more tractable algorithm ? Extension of algorithm to allow for analysis of multiple gene segments ? Analysis of existing influenza datasets ? Extension to and analysis of other RNA virus species
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 160792 |
Applicant Surname | Lumby |
Approval Committee | PhD Studentships |
Award Date | 2014-07-14T00:00:00+00:00 |
Financial Year | 2013/14 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 105365/Z/14/Z |
Lead Applicant | Mr Casper Lumby |
Partnership Value | 160792 |
Planned Dates: End Date | 2019-01-12T00:00:00+00:00 |
Planned Dates: Start Date | 2014-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Simon Tavaré |