Exploring gene therapy approaches for neuroblastoma using a patient's own gamma delta T cells. (360G-Wellcome-105749_Z_14_Z)
Neuroblastoma is a rare childhood malignancy with tumours developing from the sympathetic nervous system. Approximately 50% of patients are affected by high-risk disease characterised by widespread metastasis. Five-year survival is only 40% despite highly aggressive multi-modal treatment regimes. Novel therapies that effectively target malignant cells whilst sparing normal tissues are therefore a research priority. Adoptive cellular therapy with T-cells engineered to express a Chimeric Antigen R eceptor (CAR) combine the antigen specificity of a monoclonal antibody together with T-lymphocyte cytotoxicity. Current approaches utilise alpha-beta T-cells due there abundance in the peripheral circulation and ease of expansion ex vivo. Gamma delta T-cells (gdT) however have many unique and advantageous properties, including innate killing ability, antibody-dependent cytotoxicity and professional antigen presenting function. When engineered with a CAR, gdT-cells may therefore may confer therap eutic advantage as we hypothesise they will give better tumour responses and better long-lived protection. This pre-clinical project investigates CAR-gdT-cells as a potential novel therapy for high-risk neuroblastoma. The ultimate aim is to engineer gdT-cells that have greater specific cytotoxcity, reduced off-target effects, and the ability to generate secondary immune responses leading to long-lasting anti-tumour surveillance. If successful, we will look to opening a CAR-gdT-cell phase 1 clini cal trial.
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Grant Details
Amount Awarded | 114615 |
Applicant Surname | Capsomidis |
Approval Committee | Clinical Interview Committee |
Award Date | 2014-11-13T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Research Training Fellowship |
Internal ID | 105749/Z/14/Z |
Lead Applicant | Dr Anna Capsomidis |
Partnership Value | 114615 |
Planned Dates: End Date | 2018-09-17T00:00:00+00:00 |
Planned Dates: Start Date | 2015-10-19T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Andrew Copp |