The genomic architecture of human nucleolar organizer regions and its role in nucleolar biology . (360G-Wellcome-106199_Z_14_Z)
The human genome contains ~300 ribosomal gene (rDNA) repeats, organized in tandem arrays at nucleolar organizer regions (NORs), situated on the short p-arms of each of the five human acrocentric chromosomes. Despite harboring NORs that direct the assembly of one of the key functional domains of the nucleus (the nucleolus), acrocentric p-arms remain absent from the current human genome assembly. The research goal of my laboratory is to determine how NORs are arranged at a chromosomal level and h ow they direct formation and regulate the function of nucleoli in human cells. The research program I propose focuses on the chromosomal context of NORs and its role in nucleolar biology. It has the following three specific aims: (1) Determine the genomic architecture of acrocentric short-arms. (2) Identify and characterize elements that regulate NOR activity and nucleolar morphology. (3) Determine how the chromosomal context of NORs contributes to the genomic stability of rDNA arrays.
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Grant Details
| Amount Awarded | 565117 |
| Applicant Surname | McStay |
| Approval Committee | Science Interview Panel |
| Award Date | 2014-12-03T00:00:00+00:00 |
| Financial Year | 2014/15 |
| Grant Programme: Title | Investigator Award in Science |
| Internal ID | 106199/Z/14/Z |
| Lead Applicant | Prof Brian McStay |
| Partnership Name | SFI-HRB-Wellcome Trust partnership |
| Partnership Value | 1130235 |
| Planned Dates: End Date | 2021-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-04-01T00:00:00+00:00 |
| Recipient Org: Country | Ireland |
| Region | Ireland |