Investigating the role of TL1A-DR3 in immune complex-mediated autoimmune disease. (360G-Wellcome-106809_Z_15_Z)
In this project we propose to focus on the role of the DR3-TL1A axis in autoimmune disease and more specifically on its involvement in lupus nephritis. We will determine which subset of kidney-resident mononuclear phagocytes express TL1A following immune complex-dependent FcγR-cross-linking. We will also investigate the relative importance of DR3 expression on myeloid cells versus lymphocytes in disease pathogenesis. Finally we will address how the myeloid cells and lymphocytes interact in the kidney in vivo and determine the role of the DR3-TL1A axis in these interactions
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Grant Details
| Region | East of England |
| Award Date | 2015-01-12T00:00:00+00:00 |
| Sponsor(s) | Prof Menna Clatworthy |
| Internal ID | 106809/Z/15/Z |
| Planned Dates: End Date | 2019-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-10-01T00:00:00+00:00 |
| Amount Awarded | 80000 |
| Financial Year | 2014/15 |
| Lead Applicant | Mr Nathan Richoz |
| Grant Programme: Title | WT/NIH Four Year PhD Studentship |
| Partnership Name | Wellcome Trust-NIH PhD Studentships |
| Applicant Surname | Richoz |
| Approval Committee | WT/NIH Four Year PhD Programme Interview Committee |
| Recipient Org: Country | United Kingdom |
| Recipient Org: City | Cambridge |
| Has the grant transferred? | No |
| Research conducted at multiple locations? | No |
| Total amount including partnership funding | 80000 |