Investigating the role of TL1A-DR3 in immune complex-mediated autoimmune disease. (360G-Wellcome-106809_Z_15_Z)
In this project we propose to focus on the role of the DR3-TL1A axis in autoimmune disease and more specifically on its involvement in lupus nephritis. We will determine which subset of kidney-resident mononuclear phagocytes express TL1A following immune complex-dependent FcgammaR-cross-linking. We will also investigate the relative importance of DR3 expression on myeloid cells versus lymphocytes in disease pathogenesis. Finally we will address how the myeloid cells and lymphocytes interact in the kidney in vivo and determine the role of the DR3-TL1A axis in these interactions
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
| Amount Awarded | 80000 |
| Applicant Surname | Richoz |
| Approval Committee | WT/NIH Four Year PhD Programme Advisory Committee |
| Award Date | 2015-01-12T00:00:00+00:00 |
| Financial Year | 2014/15 |
| Grant Programme: Title | WT/NIH Four Year PhD Studentship |
| Internal ID | 106809/Z/15/Z |
| Lead Applicant | Mr Nathan Richoz |
| Partnership Name | Wellcome Trust-NIH PhD Studentships |
| Partnership Value | 80000 |
| Planned Dates: End Date | 2019-10-01T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |
| Sponsor(s) | Prof Menna Clatworthy |