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Investigating the role of TL1A-DR3 in immune complex-mediated autoimmune disease. (360G-Wellcome-106809_Z_15_Z)

<p>In this project we propose to focus on the role of the DR3-TL1A axis in autoimmune disease and more specifically on its involvement in lupus nephritis. We will determine which subset of kidney-resident mononuclear phagocytes express TL1A following immune complex-dependent Fc&gamma;R-cross-linking. We will also investigate the relative importance of DR3 expression on myeloid cells versus lymphocytes in disease pathogenesis. Finally we will address how the myeloid cells and lymphocytes interact in the kidney in vivo and determine the role of the DR3-TL1A axis in these interactions</p>


12 Jan 2015

Grant details
Amount Awarded 80000
Applicant Surname Richoz
Approval Committee WT/NIH Four Year PhD Programme Advisory Committee
Award Date 2015-01-12T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title WT/NIH Four Year PhD Studentship
Internal ID 106809/Z/15/Z
Lead Applicant Mr Nathan Richoz
Planned Dates: End Date 2019-10-01T00:00:00+00:00
Planned Dates: Start Date 2015-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Menna Clatworthy
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