Investigating the role of TL1A-DR3 in immune complex-mediated autoimmune disease. (360G-Wellcome-106809_Z_15_Z)
In this project we propose to focus on the role of the DR3-TL1A axis in autoimmune disease and more specifically on its involvement in lupus nephritis. We will determine which subset of kidney-resident mononuclear phagocytes express TL1A following immune complex-dependent FcγR-cross-linking. We will also investigate the relative importance of DR3 expression on myeloid cells versus lymphocytes in disease pathogenesis. Finally we will address how the myeloid cells and lymphocytes interact in the kidney in vivo and determine the role of the DR3-TL1A axis in these interactions
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Grant Details
| Amount Awarded | 80000 |
| Applicant Surname | Richoz |
| Approval Committee | WT/NIH Four Year PhD Programme Interview Committee |
| Award Date | 2015-01-12T00:00:00+00:00 |
| Financial Year | 2014/15 |
| Grant Programme: Title | WT/NIH Four Year PhD Studentship |
| Has the grant transferred? | No |
| Internal ID | 106809/Z/15/Z |
| Lead Applicant | Mr Nathan Richoz |
| Partnership Name | Wellcome Trust-NIH PhD Studentships |
| Planned Dates: End Date | 2019-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-10-01T00:00:00+00:00 |
| Recipient Org: City | Cambridge |
| Recipient Org: Country | United Kingdom |
| Region | East of England |
| Research conducted at multiple locations? | No |
| Sponsor(s) | Prof Menna Clatworthy |
| Total amount including partnership funding | 80000 |