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Topical delivery of Ranibizumab for non-invasive treatment of retinal disease (360G-Wellcome-106942_Z_15_Z)

Age-related macular degeneration (AMD) is a major cause of blindness, affecting 30- 50 million people worldwide, with a rising incidence due to the rapidly increasing aging population. Current treatments, of which Ranibizumab is the most frequently prescribed, involve monthly injections into the eye to block a protein known as VEGF (vascular endothelial growth factor), responsible for new blood vessel formation. However, at £85 million/year in the UK, injections carry a high burden to the health system, requiring specialist-clinic administration. There is a clear, unmet need for anti-VEGF treatments therefore to be non-invasive, easy to administer and less expensive. Professor M Francesca Cordeiro and her team at UCL have developed a formulation that can be used to replace monthly hospital-administered intraocular anti-VEGF injections with daily self-administered eye-drops. This project aims to optimize the formulation for Ranibizumab, develop its manufacturing process, and assess its safety and tolerability to enable it to be tested in First-in-Man clinical trials. If successful, the Ranibizumab eye-drop will lead to widespread treatment programmes - potentially reducing the burden of AMD on the individual and society by changing the way treatment is delivered within five to seven years.


16 Apr 2015

Grant details
Amount Awarded 1666193
Applicant Surname Cordeiro
Approval Committee Health Innovation Challenge Fund
Award Date 2015-04-16T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Health Innovation Challenge Fund Award
Internal ID 106942/Z/15/Z
Lead Applicant Prof M Francesca Cordeiro
Planned Dates: End Date 2020-09-05T00:00:00+00:00
Planned Dates: Start Date 2016-02-05T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
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