The RHiSE study (Resistant Hypertension and treatment Strategies Evaluation study). (360G-Wellcome-107340_Z_15_Z)

This project will address a clear gap in RH research. The key goals of the project are: 1) to carry out a systematic review of current treatment options in RH and to analyse their comparative effects on CV outcomes. The review will also be used to identify issues around quality of existing literature and will instruct the development of the cohort study in stage three of the Fellowship. 2) to accurately estimate the incidence and prevalence of RH in the UK using Clinical Practice Research Datalink (CPRD) data. 3) to design and execute two cohort studies, one each in a UK database and a US database, which will examine the comparative effectiveness of different treatment regimens in RH in two countries. The cohort studies will allow analysis of reductions in BP and their associations with cardiovascular outcomes in RH. A methodological issue concerning missing data in the US database will be addressed as part of key goal 3. Reaching these key goals will allow delivery of t he overall objective of the project, to support the development of evidence based clinical guidelines for RH.