Lentiviral accessory proteins Vpx and Vpr, viral countermeasures to host cell defences. (360G-Wellcome-108014_Z_15_Z)
Vpx and Vpr are lentiviral accessory proteins essential for optimal virus replication. They implement the destruction of host-cell defence proteins that would otherwise inhibit virus replication. Our primary objective is to understand Vpx/Vpr function at the molecular level. To address this question we will ask: (i) how Vpx/Vpr interact with their cellular targets (ii) whether we can change the activities of these cellular factors by modulating interactions through Vpx/Vpr (iii) the consequen ces for virus and host of altering these activities
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Grant Details
| Amount Awarded | 731919 |
| Applicant Surname | Taylor |
| Approval Committee | Science Interview Panel |
| Award Date | 2015-07-07T00:00:00+00:00 |
| Financial Year | 2014/15 |
| Grant Programme: Title | Investigator Award in Science |
| Internal ID | 108014/Z/15/Z |
| Lead Applicant | Dr Ian Taylor |
| Partnership Value | 731919 |
| Planned Dates: End Date | 2021-11-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-12-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |