Characterising the spatial determinants of antimalarial resistance in P. falciparum malaria (360G-Wellcome-109312_Z_15_A)
At present artemisinin-based combination therapies (ACT) are recommended for the treatment of uncomplicated malaria and are hoped to limit possible development of antimalarial resistance. Recent observations of ACT resistance in Southeast Asia however indicates that the emergence of clinical resistance is occurring, indicating that parasites may be developing resistance to both components of the ACT. It is thus imperative that a course of action for balancing both the longevity of antimalarial efficacy and the immediate public health impact is identified. We aim to develop a spatial individual stochastic model of malaria transmission that incorporates both the epidemiological and within host process in order to better understand the drivers of ACT resistance emergence. Through this endeavour we aim to identify strategies at regional levels within Southeast Asia in order to slow the speed of ACT resistance. Finally we will predict and map the potential future burden of ACT resistance within Southeast Asia.
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Grant Details
| Amount Awarded |
0
|
| Applicant Surname | Watson |
| Approval Committee | Internal Decision Panel |
| Award Date | 2017-01-31T00:00:00+00:00 |
| Financial Year | 2016/17 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 109312/Z/15/A |
| Lead Applicant | Dr Oliver Watson |
| Partnership Value | 0 |
| Planned Dates: End Date | 2019-10-02T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-10-03T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |