Defining host and viral factors that are associated with hepatitis B virus control and clearance in Caucasian and African adults. (360G-Wellcome-110110_A_15_Z)
HBV accounts for a significant global burden of liver disease. This project is founded on the urgent need to characterise T cell responses in order to enhance our understanding of differential outcomes of infection, and underpin future immunotherapeutic strategies. I will recruit a multi-centre cohort of adults with chronic hepatitis B infection (CHB) in Africa and the UK, to study factors associated with immune containment of HBV. Viral activity will be assessed using serum markers (HBeAg s tatus, HBsAg level, HBV DNA viral load). I will undertake deep sequencing of full length virus, first to identify patterns of selection of viral polymorphisms, and then to correlate these with changes in these biomarkers. Secondly, as CD8+ T cells may contribute to HBV suppression, I will use a computational algorithm to identify sites of HLA Class I mediated selection in HBV. These footprints can be used to identify sites of novel T cell epitopes and to identify polymorphisms that may impact on viral fitness. I will assess the impact of host factors that may have influence on this immunological containment, including age, gender and HIV co- infection. Overall, these data will provide unique insights into HBV immune control.
Where is this data from?
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Grant Details
| Region | London |
| Award Date | 2015-11-19T00:00:00+00:00 |
| Sponsor(s) | Prof Eleanor Barnes, Prof Paul Klenerman, Prof Philip Goulder |
| Internal ID | 110110/A/15/Z |
| Planned Dates: End Date | 2023-10-22T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-08-01T00:00:00+00:00 |
| Amount Awarded | 1285125 |
| Financial Year | 2015/16 |
| Lead Applicant | Prof Philippa Clare Matthews |
| Grant Programme: Title | Residual Award |
| Applicant Surname | Matthews |
| Approval Committee | Clinical Interview Committee |
| Recipient Org: Country | United Kingdom |
| Recipient Org: City | London |
| Has the grant transferred? | Yes |
| Research conducted at multiple locations? | Yes |
| Total amount including partnership funding | 1285125 |