Improving the efficacy of malaria prevention in an insecticide resistant Africa (360G-Wellcome-200222_C_15_Z)

£128,667

Impressive reductions in malaria have occurred throughout sub-Saharan Africa over the past 12 years. However progress has not been geographically uniform and there are some high-burden countries where, despite good coverage with long lasting insecticide-treated nets (LLINs), the main preventative measure recommended by WHO, parasite prevalence rates and mortality from malaria remain obstinately high. Burkina Faso falls into this category. Despite two successful national LLIN distribution campaigns 60 % of children are persistently infected with malaria. Increased resistance to the pyrethroid insecticides used in LLINs and extensive transmission by mosquitoes biting outside the home, or at times when people are not protected by LLINs, are likely reducing the impact of LLINs but the relative importance of these poorly characterised vector factors, in relation to other human or health system factors has never been determined. This project will collect extensive empirical data and use models of malaria transmission to quantify the level of protection provided by LLINs in an insecticide resistant Africa. Via a detailed understanding of the factors limiting the efficacy of current tools we will identify the most cost effective, complementary interventions that would drive malaria transmission towards zero.

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Grant Details

Amount Awarded 128667
Applicant Surname Lindsay
Award Date 2015-12-08T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Collaborative Award in Science
Internal ID 200222/C/15/Z
Lead Applicant Prof Steve Lindsay
Other Applicant(s) Dr Caroline Jones, Dr Eve Worrall, Dr Sagnon N'Fale, Dr Thomas Churcher, Dr Tiono Alfred B, Prof David Towers, Prof Heather Ferguson, Prof Hilary Ranson, Prof Jason Matthiopoulos, Prof Philip McCall
Partnership Value 128667
Planned Dates: End Date 2019-10-31T00:00:00+00:00
Planned Dates: Start Date 2016-05-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North East