The Genome Campus Alliance (360G-Wellcome-201535_Z_16_Z)

The Global Alliance for Genomics and Health (GA4GH) is an international consortium committed to sharing genomic and clinical data to address pressing research questions and to develop innovative clinical applications. Its major activity is to develop open technical and operational standards. However, translating these standards into concrete solutions requires implementation and testing of the proposed interfaces and practices, and incorporation of these experiences into the standards process. To date, this effort has been done largely by volunteers and it has lacked a coordinated effort to deploy the developed solutions. The Genome Campus Alliance (GCA) is a collaboration of the European Bioinformatics Institute (EMBL-EBI), the Wellcome Trust Sanger Institute (WTSI) and ELIXIR to create, deploy and manage an "at-scale" implementation of the GA4GH reference standards and application programming interfaces (APIs). We will leverage our experience with large-scale service resources to create open source tools designed to access existing data resources at EMBL-EBI and WTSI using the GA4GH methods and interoperability standards. We will make these tools available to GA4GH-member Genomics England, and use them ourselves to analyse 100,000 Genomes data. Through ELIXIR, we will identify shareable data, coordinate GA4GH compatible implementations across Europe and deliver training to maximise GCA's impact.