Screening thalidomide analogs in Chicken and Zebrafish embryos (360G-Wellcome-201875_Z_16_Z)
The 8-week scholarship will involve screening 15 Thalidomide analogs on both chicken and zebrafish embryos to test for whether they present teratogenic, antiangiogenic and/or anti-inflammatory effects. The chicken embryos will be used to analyse the effects of the analogues on embryogenesis. Two strains of zebrafish will be used; Fli-1EGFP strain has GFP-tagged endothelial cells and can be used to determine whether an analog is anti-angiogenic, and the MPO-GFP strain has GFP-tagged neutrophils and can be used to determine whether an analogue has anti-inflammatory effects. Further analysis can be performed using ELISA assays of TNFalpha to determine the potency of the analogs.
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Grant Details
| Amount Awarded | 2000 |
| Applicant Surname | Berg |
| Approval Committee | Internal Decision Panel for C&S |
| Award Date | 2016-04-01T00:00:00+00:00 |
| Financial Year | 2015/16 |
| Grant Programme: Title | Vacation Scholarships |
| Internal ID | 201875/Z/16/Z |
| Lead Applicant | Miss Amanda Berg |
| Partnership Value | 2000 |
| Planned Dates: End Date | 2016-08-13T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-06-13T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |