Blood vessel activation in inflamatory arthritis (360G-Wellcome-202369_Z_16_Z)
In inflammatory arthritis, articular blood vessels become activated and mediate trans-endothelial migration (transmigration) of blood borne immune cells into the affected synovium and joint space1. Immune cell transmigration also occurs in dorsal root ganglia (DRG) in a model of inflammatory arthritis and these cells contribute to the development of pain2. We hypothesise that blocking blood vessel activation, thereby preventing immune cell infiltration into the DRG, will inhibit the development of pain in inflammatory arthritis. The Student will undertake histological work to investigate the degree of immune cell DRG transmigration in arthritic animals treated with compounds to inhibit endothelial activation and immune cell transmigration. 1. Kinne RW, Stuhlmuller B, Burmester GR. Cells of the synovium in rheumatoid arthritis. Macrophages. Arthritis Res Ther 2007;9(6):224 2. Segond von Banchet G, Boettger MK, Fischer N, Gajda M, Brauer R, Schaible HG. Experimental arthritis causes tumor necrosis factor-alpha-dependent infiltration of macrophages into rat dorsal root ganglia which correlates with pain-related behavior. Pain 2009;145(1-2):151-9
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Grant Details
| Amount Awarded | 2000 |
| Applicant Surname | Ashby |
| Approval Committee | Internal Decision Panel for C&S |
| Award Date | 2016-04-01T00:00:00+00:00 |
| Financial Year | 2015/16 |
| Grant Programme: Title | Vacation Scholarships |
| Internal ID | 202369/Z/16/Z |
| Lead Applicant | Mr William Ashby |
| Partnership Value | 2000 |
| Planned Dates: End Date | 2016-08-06T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-06-06T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East Midlands |