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The regulation of microRNAs in cartilage by circadian rhythms (360G-Wellcome-202400_Z_16_Z)

Osteoarthritis (OA) is a degenerative joint disease and a leading cause of disability in the UK. There is currently no pharmaceutical cure for OA and pain relief is rapidly inadequate. The role of both microRNAs (miRs) and the circadian rhythm in OA have recently come to the fore, and a clear involvement for both areas in cartilage homeostasis has been identified. However, there are no data on the control of miRs in cartilage by circadian rhythms. This proposal aims to: (i) measure expression of cartilage-relevant miRs in synchronised chondrocyte cell cultures to identify those expressed in a circadian fashion; (ii) validate CLOCK as a direct target of miR-455, predicted by bioinformatics. This will provide initial data on the role of the circadian rhythm in miR expression in cartilage and inform on novel therapeutic strategies in OA.


01 Apr 2016

Grant details
Amount Awarded 2000
Applicant Surname Lines
Approval Committee Internal Decision Panel for C&S
Award Date 2016-04-01T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Vacation Scholarships
Internal ID 202400/Z/16/Z
Lead Applicant Mr George Lines
Planned Dates: End Date 2016-08-12T00:00:00+00:00
Planned Dates: Start Date 2016-06-12T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
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