The regulation of microRNAs in cartilage by circadian rhythms (360G-Wellcome-202400_Z_16_Z)
Osteoarthritis (OA) is a degenerative joint disease and a leading cause of disability in the UK. There is currently no pharmaceutical cure for OA and pain relief is rapidly inadequate. The role of both microRNAs (miRs) and the circadian rhythm in OA have recently come to the fore, and a clear involvement for both areas in cartilage homeostasis has been identified. However, there are no data on the control of miRs in cartilage by circadian rhythms. This proposal aims to: (i) measure expression of cartilage-relevant miRs in synchronised chondrocyte cell cultures to identify those expressed in a circadian fashion; (ii) validate CLOCK as a direct target of miR-455, predicted by bioinformatics. This will provide initial data on the role of the circadian rhythm in miR expression in cartilage and inform on novel therapeutic strategies in OA.
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Grant Details
| Amount Awarded | 2000 |
| Applicant Surname | Lines |
| Approval Committee | Internal Decision Panel for C&S |
| Award Date | 2016-04-01T00:00:00+00:00 |
| Financial Year | 2015/16 |
| Grant Programme: Title | Vacation Scholarships |
| Internal ID | 202400/Z/16/Z |
| Lead Applicant | Mr George Lines |
| Partnership Value | 2000 |
| Planned Dates: End Date | 2016-08-12T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-06-12T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |