Synthesis and characterisation of a cyclic peptide protein-protein interaction inhibitor. (360G-Wellcome-202414_Z_16_Z)
The student will synthesize analogues of a cyclic peptide protein-protein interaction inhibitor, that selectively disrupts dimerization of C-terminal binding protein (CtBP), a transcriptional co-repressor that plays a key role in tumour development. The synthesized molecule is expected to have improved potency based on a crystal structure of the peptide/protein complex.They will express the target protein and assess the binding affinity by ITC and MST. This will provide experience in a range of multidisicplinary techniques.
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Grant Details
| Amount Awarded | 2000 |
| Applicant Surname | Mason |
| Approval Committee | Internal Decision Panel for C&S |
| Award Date | 2016-04-01T00:00:00+00:00 |
| Financial Year | 2015/16 |
| Grant Programme: Title | Vacation Scholarships |
| Internal ID | 202414/Z/16/Z |
| Lead Applicant | Mr Henry Mason |
| Partnership Value | 2000 |
| Planned Dates: End Date | 2016-09-24T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-07-25T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |