King’s NMR Facility for structural biology, metabolic profiling and drug discovery (360G-Wellcome-202767_Z_16_Z)

We seek a one-third contribution from the Trust towards the acquisition of 800MHz and 600MHz NMR spectrometers and resources for automation to be housed within the existing NMR Facility in the Centre for Biomolecular Spectroscopy at King’s. The new equipment will deliver higher resolution, sensitivity and throughput and enjoy the benefits of the very latest advances in electronics, probe design and automation, enabling the implementation of new methodologies that are not possible on the current instrumentation. This will create a state-of-the-art centre for high-resolution and high-throughput applications to support a large and vibrant research community (including several externally-funded Centres) that has experienced a remarkable growth in NMR-based research, from structural biology to drug discovery and metabolomics. The expanded Facility will provide a centre for scientists from 18 departments spread over 4 Faculties, including biologists, chemists and clinicians. It will promote exchange of ideas and catalyse unique and innovative interdisciplinary approaches for tackling fundamental biomedical questions and meeting new therapeutic challenges in the fields of cardiovascular disease, neurological disorders, diseases of pregnancy, viral infections and cancer. This instrumentation will support King’s major strategic goal of fostering close relationships between basic and clinical scientists, aiming to provide real benefits for human health.