TwinsUK (2017-2019): An epidemiological and genomic resource (360G-Wellcome-202786_Z_16_Z)

Funding is requested to maintain TwinsUK resource, of 13,000 twins with over 300,000 longitudinal samples and the most detailed phenotypes and “omics” of any UK cohort. Continuing extensive data sharing (700 data requests and 90,000 samples to researchers in the last five years), the TwinsUK resource will make further contributions to biomedical science over the next decade. Key objectives are: Continue the TwinsUK Registry providing support for core staff (85% of budget) and facilitate data sharing with scientists (aim 120/year). Maintain and improve open access to the data and samples by improving data access systems (“Phenobase2” database to go live). Further upgrade the extensive biobank of biological samples adding new and longitudinal DNA samples to UKBiocentre’s robotic facility (8,000 samples). Replenish DNA stocks in 800 of our most valuable twins to ensure increased sample availability and long-term use. Digitise paper records for secure access and storage. Address attrition of valuable frail participants targeting 250 twins/year through a dedicated assistant for continuity of contact and home packs to enable data and DNA collections Pilot data linkage with NHS health data using a subset of twins with practices already registered with the national CPRD (Clinical Practice Research Datalink, http://www.cprd.com/intro.asp) and HSCIC.