Regulatory potential of repeat elements in the evolution of tissue-specific transcription (360G-Wellcome-202878_Z_16_Z)
The human genome, like all mammalian genomes, is in large part composed of decayed--but once active--repeat elements, many of which carry tissue-specific regulatory information. We hypothesise that repurposing of repeats has been critical for creating tissue-specific transcriptional regulation. Our research plan is an integrated experimental and computational strategy to systematically explore how these repeat elements have shaped the regulatory genome across the recent placental mammalian radiation.
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Grant Details
| Region | East of England |
| Award Date | 2016-07-05T00:00:00+00:00 |
| Internal ID | 202878/Z/16/Z |
| Planned Dates: End Date | 2022-12-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2017-01-01T00:00:00+00:00 |
| Amount Awarded | 1715976 |
| Financial Year | 2015/16 |
| Lead Applicant | Dr Duncan T Odom |
| Grant Programme: Title | Investigator Award in Science |
| Applicant Surname | Odom |
| Approval Committee | Science Interview Panel |
| Other Applicant(s) | Dr Paul Flicek |
| Recipient Org: Country | United Kingdom |
| Recipient Org: City | Cambridge |
| Has the grant transferred? | No |
| Research conducted at multiple locations? | Yes |
| Total amount including partnership funding | 1715976 |