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Regulatory potential of repeat elements in the evolution of tissue-specific transcription (360G-Wellcome-202878_Z_16_Z)

The human genome, like all mammalian genomes, is in large part composed of decayed--but once active--repeat elements, many of which carry tissue-specific regulatory information. We hypothesise that repurposing of repeats has been critical for creating tissue-specific transcriptional regulation. Our research plan is an integrated experimental and computational strategy to systematically explore how these repeat elements have shaped the regulatory genome across the recent placental mammalian radiation.

£1,715,976

05 Jul 2016

Grant details
Amount Awarded 1715976
Applicant Surname Odom
Approval Committee Science Interview Panel
Award Date 2016-07-05T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Investigator Award in Science
Internal ID 202878/Z/16/Z
Lead Applicant Dr Duncan Odom
Other Applicant(s) Dr Paul Flicek
Planned Dates: End Date 2022-01-01T00:00:00+00:00
Planned Dates: Start Date 2017-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
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