Regulatory potential of repeat elements in the evolution of tissue-specific transcription (360G-Wellcome-202878_Z_16_Z)
The human genome, like all mammalian genomes, is in large part composed of decayed--but once active--repeat elements, many of which carry tissue-specific regulatory information. We hypothesise that repurposing of repeats has been critical for creating tissue-specific transcriptional regulation. Our research plan is an integrated experimental and computational strategy to systematically explore how these repeat elements have shaped the regulatory genome across the recent placental mammalian radiation.
£1,715,976 05 Jul 2016