Regulatory potential of repeat elements in the evolution of tissue-specific transcription (360G-Wellcome-202878_Z_16_Z)
The human genome, like all mammalian genomes, is in large part composed of decayed--but once active--repeat elements, many of which carry tissue-specific regulatory information. We hypothesise that repurposing of repeats has been critical for creating tissue-specific transcriptional regulation. Our research plan is an integrated experimental and computational strategy to systematically explore how these repeat elements have shaped the regulatory genome across the recent placental mammalian radiation.
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Grant Details
Amount Awarded | 1715976 |
Applicant Surname | Odom |
Approval Committee | Science Interview Panel |
Award Date | 2016-07-05T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 202878/Z/16/Z |
Lead Applicant | Dr Duncan Odom |
Other Applicant(s) | Dr Paul Flicek |
Partnership Value | 1715976 |
Planned Dates: End Date | 2022-12-31T00:00:00+00:00 |
Planned Dates: Start Date | 2017-01-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |