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BRAINEACv2: a resource for the interpretation of genetic variation in multiple regions of the adult human brain (360G-Wellcome-202903_Z_16_Z)

We aim to create BRAINEACv2, a resource for the investigation of the impact of genetic variation on gene expression in adult human brain. This resource will include three types of data: expression quantitative trait loci (eQTL), allele-specific expression and gene co-expression networks. Given the regional, cellular and molecular complexity of human brain, we believe there is a strong case for the creation of a tissue-specific resource. At present no comprehensive resource of this kind exists. However, our own public resource, BRAINEACv1, provides strong evidence for the popularity of such a resource with ~900 users from >80 countries accessing the website monthly. If funded BRAINEACv2 will represent a step-change improvement. It will include all 3 types of data described above (eQTL, ASE and co-expression networks), incorporate RNA-seq based gene expression quantification results and will include data from other major consortia (e.g. the North American Brain Expression Consortium). Given the success we have already demonstrated in creating a brain-specific resource for variant interpretation in human brain, we are well placed to deliver a new, comprehensive resource capable of meeting the growing interest in the understanding of the genetic regulation of gene expression in adult human brain.

£205,514

16 Jun 2016

Grant details
Amount Awarded 205514
Applicant Surname Hardy
Approval Committee Biomedical Resource and Technology Development Committee
Award Date 2016-06-16T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Biomedical Resources Grant
Internal ID 202903/Z/16/Z
Lead Applicant Prof John Hardy
Other Applicant(s) Dr Mina Ryten
Planned Dates: End Date 2019-09-30T00:00:00+00:00
Planned Dates: Start Date 2016-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
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