Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

BRAINEACv2: a resource for the interpretation of genetic variation in multiple regions of the adult human brain (360G-Wellcome-202903_Z_16_Z)

We aim to create BRAINEACv2, a resource for the investigation of the impact of genetic variation on gene expression in adult human brain. This resource will include three types of data: expression quantitative trait loci (eQTL), allele-specific expression and gene co-expression networks. Given the regional, cellular and molecular complexity of human brain, we believe there is a strong case for the creation of a tissue-specific resource. At present no comprehensive resource of this kind exists. However, our own public resource, BRAINEACv1, provides strong evidence for the popularity of such a resource with ~900 users from >80 countries accessing the website monthly. If funded BRAINEACv2 will represent a step-change improvement. It will include all 3 types of data described above (eQTL, ASE and co-expression networks), incorporate RNA-seq based gene expression quantification results and will include data from other major consortia (e.g. the North American Brain Expression Consortium). Given the success we have already demonstrated in creating a brain-specific resource for variant interpretation in human brain, we are well placed to deliver a new, comprehensive resource capable of meeting the growing interest in the understanding of the genetic regulation of gene expression in adult human brain.


16 Jun 2016

Grant details
Amount Awarded 205514
Applicant Surname Hardy
Approval Committee Biomedical Resource and Technology Development Committee
Award Date 2016-06-16T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Biomedical Resources Grant
Internal ID 202903/Z/16/Z
Lead Applicant Prof John Hardy
Other Applicant(s) Dr Mina Ryten
Planned Dates: End Date 2019-09-30T00:00:00+00:00
Planned Dates: Start Date 2016-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Additional data added by GrantNav