(Pilot) Development grant for a multicentre, randomised trial to reduce surgical site infection following emergency gastrointestinal surgery (360G-Wellcome-202981_Z_16_Z)

SPECIFIC DEVELOPMENT GRANT OBJECTIVES:1. To produce a working, finalised trial protocol based on selected interventions that will act as the framework for acompetitive application in 2017 (to either the Joint Global Health Trials Scheme or equivalent available programme).2. To select clear interventions with local stakeholder engagement that are important, relevant and deliverable in low andmiddle income countries (LMICs).3. To develop individualised plans for implementation and quality assurance of the selected interventions.4. To create individualised plans for 30-day follow-up at each site, by developing a predicted plan including outpatient,mobile telephone and home visit assessments.5. To confirm our sample size calculation.6. To train and develop local surgical research skills capacity, enabling surgeon principle investigators to develop their ownresearch 'hub and spoke' networks.LONGTERM NETWORK OBJECTIVES: The broader objective of the collaborative is to develop a network that cancontinue deliver large, pragmatic gastrointestinal surgical trials across LMICs in the future. We envisage harmonising eachsite's administration so that trials can be delivered with increasing speed in the future. These trials will hopefully be largerand of increasing complexity, spanning a range of perioperative care issues that will reduce morbidity and mortality. Wealso aim to disseminate our NHS based 'hub and spoke' surgical network models to LMIC settings, developing lastingcultures of research skills. We will support and train local lead surgeons to lead their own networks.