Extension Request for Wellcome Centre for Cell-Matrix Research (360G-Wellcome-203128_A_16_Z)

Matrix accounts for two-thirds of total protein mass and provides the scaffolds necessary for cell function and tissue health. Consequently, matrix dysregulation is central to ageing and the pathogenesis of major human chronic diseases affecting all organ systems. Discoveries in the Centre have shown that synthesis and degradation of matrix is under circadian clock control, we have identified immunomodulatory pathogen proteins that tether to the matrix during gut infection, and have identified specialised adhesion complexes that mediate cell migration, division and attachment to matrix. We are learning how to regulate matrix synthesis, have unravelled the disease mechanism in a chondrodysplasia, and developed a biologic for the treatment of osteoarthritis and dry eye disease. These, and other Centre discoveries described below were only possible when researchers with complementary approaches worked together in a collaborative environment underpinned by exceptional core facilities. Importantly, we have learned the value of incorporating bioinformatics and mathematics into our research programmes. We are applying for a 2-year extension to our Core Award to implement predictive mathematical modelling, machine learning, and bioinformatics throughout the Centre, maintain our Core Facilities and make ground-breaking discoveries that underpin all of biomedical research and translation combined with a strong public involvement programme.