Core Funding Extension for the Wellcome Centre for Human Genetics (360G-Wellcome-203141_A_16_Z)

We are a research community of basic and clinician scientists on an inter- disciplinary hospital campus with extensive outreach to Oxford’s tropical medicine units and global health challenges. Our vision is improving human health by maximising the informativeness of human genetics and disease mechanisms. We commit to: Responding to clinical need, making discoveries in biology to investigate genome function, translating them to molecular-cellular structures and mechanisms, and investigating impact of variation between individuals and cells, with disease and clinical outcomes. Enabling through technology, using genetics/genomics, bioinformatics, structure determination, computing, and cell/mouse genome editing, underpinned by world-leading core facilities, to understand human physiology and pathology. Data, results, materials, software, and knowhow are made fully accessible. Translating knowledge to the clinic and, where appropriate, filing patents and establishing partnerships, within the University and wider academic, technology, and biomedical sectors. Promoting a positive research culture and building capacity in people and expertise, for all staff, including enabling early-career researchers to test ideas and flourish with essential support from our core facilities. This extension will enable us to capitalize on, and extend, significant innovations since 2016, developing the next generation of innovative, game-changing technologies, approaches, and researchers, to meet still-existing and emerging threats to health.