Investigating the potential of the microbiome to improve the accuracy of the NHS Bowel Cancer Screening Programme (NHSBCSP) (360G-Wellcome-203524_Z_16_Z)
This PhD will analyse the microbiomes of a cohort of the NHSBCSP directly from stool on guaiac Faecal Occult Blood Test (gFOBT) cards using 16SrRNA Next Generation Sequencing (NGS). Goals: 1) Characterise microbiome signatures of participants with a positive gFOBT result but normal colonoscopies. These microbiome signatures will identify false positive results, improve specificity and reduce unnecessary colonoscopies. 2) Characterise microbiome signatures of participants with a positive gFOBT result who have pathology at colonoscopy. Subsequently search for these signatures within a gFOBT negative cohort to identify false negatives and improve sensitivity. 3) Interrogate microbiome signatures to identify panels of biomarker bacteria which could be detected by qPCR rather than NGS. 4) Design a protocol to extract bacterial DNA directly from FIT (Faecal Immunochemical Test), enabling the research to transition as FIT replaces gFOBT. 5) Compare microbiome signatures from consecutive biennial screens to demonstrate the stability of microbiome signatures over time. These goals will demonstrate that incorporating microbiome analysis into the NHSBCSP: is feasible will improve sensitivity/specificity adds value, by detecting both bleeding and non-bleeding cancers could be used: to collect longitudinal population-based microbiome data; to screen for microbiome-associated diseases other than colorectal cancer; to perform national monitoring of antibiotic resistance.
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Grant Details
Amount Awarded | 196056 |
Applicant Surname | Young |
Approval Committee | Clinical Interview Committee |
Award Date | 2016-06-29T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Research Training Fellowship |
Internal ID | 203524/Z/16/Z |
Lead Applicant | Dr Caroline Young |
Partnership Value | 196056 |
Planned Dates: End Date | 2020-01-30T00:00:00+00:00 |
Planned Dates: Start Date | 2016-12-03T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Yorkshire and the Humber |
Sponsor(s) | Prof Philip Quirke |