Translational neuroimaging in Huntington’s Disease: a time-course analysis of HD-related effects on myelination (360G-Wellcome-204005_Z_16_A)
Huntington’s disease (HD) is a genetic, progressive, neurodegenerative disorder leading to cognitive deficits such as difficulties in information processing, attention and executive functions. Currently, this devastating disorder cannot be cured, hence the importance of gaining an insight into its pathogenesis and of looking for biomarkers of treatments’ efficacy. Evidence shows that HD is associated with white matter (WM) degeneration. Further, myelin break-down has been implicated in WM deterioration in HD. This emphasizes the potential of quantitative MRI metrics assessing white matter microstructure and myelination, to inform about disease pathogenesis. However, demyelination remains relatively unexplored in HD as compared to other neurodegenerative diseases. The purpose of the present research project is to carry out a time-course analysis of HD-related effects on myelination, by employing novel quantitative MRI techniques to uniquely combine whole-brain myelin mapping with assessment of axonal morphology.
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Grant Details
| Amount Awarded |
0
|
| Applicant Surname | Casella |
| Approval Committee | Internal Decision Panel |
| Award Date | 2018-09-30T00:00:00+00:00 |
| Financial Year | 2017/18 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 204005/Z/16/A |
| Lead Applicant | Dr Chiara Casella |
| Partnership Value | 0 |
| Planned Dates: End Date | 2020-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2017-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Wales |