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The translational potential of mass spectrometry and next-generation sequencing in patients with central nervous system infections in Vietnam (360G-Wellcome-204904_Z_16_Z)

<p>Central nervous system (CNS) infections are devastating conditions worldwide, especially in low- and middle-income counties (LMIC). Clinical outcomes are dependent upon the rapid identification of the causative agent and instituting effective antimicrobial therapy, although the causative agent is only identified in &lt;50% of patients. Furthermore, Southeast Asia is highly susceptible to the emergence of novel and drug resistant pathogens. New diagnostic techniques are urgently required for rapid response to future outbreaks, and to improve patient outcomes.</p> <p>This Fellowship will focus on the translational potential of mass spectrometry and next-generation sequencing (NGS) in clinical diagnostics of CNS infections in Vietnam, and has three key goals:</p> <ol> <li>To determine whether Mass spectrometry of cerebrospinal fluid (CSF) will identify protein/peptide signatures associated with different infectious aetiologies.</li> <li>To determine whether NGS-based metagenomic analysis will identify a broad range of known/unknown pathogens in the CSF and improve upon current standard laboratory assays.</li> <li>To determine whether NGS can provide rapid, whole genome sequence-based prediction of antimicrobial susceptibility for <em>Mycobacterium tuberculosis</em> and <em>Streptococcus pneumoniae</em>. &nbsp;</li> </ol> <p>I aim to provide proof-of-principle that CSF proteomics- and NGS-based methods can improve upon the diagnostic assays currently available in hospital settings, especially in LMIC, and thereby potentially improve patient outcomes.</p>

£685,086

22 Nov 2016

Grant details
Amount Awarded 685086
Applicant Surname Le Van
Approval Committee International Interview Committee
Award Date 2016-11-22T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title International Intermediate Fellowship
Internal ID 204904/Z/16/Z
Lead Applicant Dr Tan Le Van
Planned Dates: End Date 2022-04-01T00:00:00+00:00
Planned Dates: Start Date 2017-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Guy Thwaites
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