Establishing causal relationships from phenotypic, genotypic, and proteomic data. (360G-Wellcome-204979_Z_16_Z)
This project aims, using adrenomedullin and hypertension as an exemplar, to demonstrate the utility of using Mendelian randomisation and experimentally validated local-protein quantitative trait loci (pQTL) in combination. Local- pQTL are pQTL that map to the approximate location of their gene-of-origin. I will determine local-pQTL for the protein adrenomedullin in two isolated cohorts, one from Orkney, Scotland, and the other from Vis, Croatia. I will validate the core assumptions underlying Mendelian randomisation for one of these local-pQTL and determine, in vitro, the effects of polymorphisms at this site on ADM (which encodes adrenomedullin) gene expression and protein concentration. Finally, I will perform Mendelian randomisation in large genotyped datasets. Collectively, this will provide evidence for, or against, a causal effect of adrenomedullin on blood pressure, and represents a paradigm for assessing the causal relationships between other protein intermediates and complex traits.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
| Region | Scotland |
| Award Date | 2016-09-30T00:00:00+00:00 |
| Sponsor(s) | Prof Brian Walker |
| Internal ID | 204979/Z/16/Z |
| Planned Dates: End Date | 2019-07-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-08-01T00:00:00+00:00 |
| Amount Awarded | 233584 |
| Financial Year | 2015/16 |
| Lead Applicant | Dr Andrew David Bretherick |
| Grant Programme: Title | PhD Training Fellowship for Clinicians |
| Applicant Surname | Bretherick |
| Approval Committee | Internal Decision Panel |
| Recipient Org: Country | United Kingdom |
| Recipient Org: City | Edinburgh |
| Has the grant transferred? | No |
| Research conducted at multiple locations? | No |
| Total amount including partnership funding | 233584 |