Organization of large neuronal populations during behavior (360G-Wellcome-205093_Z_16_Z)
Behavior arises from the coordinated function of vast numbers of neurons across the brain. However, we lack answers to fundamental questions concerning this coordinated function. How is the activity of multiple brain areas globally structured? How does this global structure relate to the firing of local neuronal populations? And what is the role of this coordination in producing animal behavior? Until recently, these questions were barely answerable: one could only record from tens or hundreds of neurons, and during single behaviors. They are now answerable, thanks to new, powerful techniques available in the brain of the mouse: optical recordings of over 10,000 neurons simultaneously, optical and ultrasound measures of mesoscopic activity in multiple brain regions, next-generation electrode arrays that record thousands of neurons across multiple areas, and temporally targeted optogenetic manipulations. We will combine these techniques to understand how brain-wide neuronal populations operate in the mouse brain during different behavioral conditions: rest, passive sensory stimulation, locomotion, sensory discrimination, and goal-directed navigation. These data will provide an unprecedented view on the neuronal-level organization of populations across the brain during behavior.
Where is this data from?
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Grant Details
Amount Awarded | 3642870 |
Applicant Surname | Carandini |
Approval Committee | Science Interview Panel |
Award Date | 2016-11-30T00:00:00+00:00 |
Financial Year | 2016/17 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 205093/Z/16/Z |
Lead Applicant | Prof Matteo Carandini |
Other Applicant(s) | Prof Kenneth Harris |
Partnership Value | 3642870 |
Planned Dates: End Date | 2023-03-31T00:00:00+00:00 |
Planned Dates: Start Date | 2017-04-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |