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Organization of large neuronal populations during behavior (360G-Wellcome-205093_Z_16_Z)

<p>Behavior arises from the coordinated function of vast numbers of neurons across the brain. However, we lack answers to fundamental questions concerning this coordinated function. How is the activity of multiple brain areas globally structured? How does this global structure relate to the firing of local neuronal populations? And what is the role of this coordination in producing animal behavior?</p> <p>&nbsp;</p> <p>Until recently, these questions were barely answerable: one could only record from tens or hundreds of neurons, and during single behaviors. &nbsp;They are now answerable, thanks to new, powerful techniques available in the brain of the mouse: optical recordings of over 10,000 neurons simultaneously, optical and ultrasound measures of mesoscopic activity in multiple brain regions, next-generation electrode arrays that record thousands of neurons across multiple areas, and temporally targeted optogenetic manipulations.</p> <p>&nbsp;</p> <p>We will combine these techniques to understand how brain-wide neuronal populations operate in the mouse brain during different behavioral conditions: rest, passive sensory stimulation, locomotion, sensory discrimination, and goal-directed navigation. These data will provide an unprecedented view on the neuronal-level organization of populations across the brain during behavior.</p>

£3,642,870

30 Nov 2016

Grant details
Amount Awarded 3642870
Applicant Surname Carandini
Approval Committee Science Interview Panel
Award Date 2016-11-30T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Investigator Award in Science
Internal ID 205093/Z/16/Z
Lead Applicant Prof Matteo Carandini
Other Applicant(s) Prof Kenneth Harris
Planned Dates: End Date 2022-04-01T00:00:00+00:00
Planned Dates: Start Date 2017-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
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