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Using visual dysfunction to understand dementia in Parkinson’s disease (360G-Wellcome-205167_Z_16_Z)

<p>Dementia affects half of patients with Parkinson&rsquo;s disease (PD) but there are no robust measures to predict who is at highest risk. Visual hallucinations are highly distressing to patients and carers but are poorly understood. This Fellowship will use visuo-perceptual dysfunction to predict dementia and understand hallucinations in PD.</p> <p>I have developed a novel test using skewed images to detect visuo-perceptual deficits in Parkinson&rsquo;s patients. I have also developed a web-based platform to enable this and other visual tests to be accessed by large numbers of patients with PD.</p> <p>In this proposal I will use visual perceptual tests combined with neuroimaging over time to determine the sequence of visuo-perceptual deficits in PD. I will relate these to changes in hallucinations. I will use my web-based platform to identify clinical and genetic associations with visual deficits and determine their role in predicting dementia in PD.</p> <p>Goals</p> <p>1. Characterise changes in visuo-perception as PD progresses and correlate deficits with brain atrophy.</p> <p>2. Relate MRI structural connectivity changes with disease progression.</p> <p>3. Examine clinical and genetic associations of visual dysfunction in PD.</p> <p>4. Test whether transcranial stimulation can improve visuo-perceptual function in PD.</p> <p>5. Determine how visual hallucinations become distressing as PD advances.</p>

£1,223,282

06 Dec 2016

Grant details
Amount Awarded 1223282
Applicant Surname Weil
Approval Committee Clinical Interview Committee
Award Date 2016-12-06T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Clinical Research Career Development Fellowship
Internal ID 205167/Z/16/Z
Lead Applicant Dr Rimona Weil
Planned Dates: End Date 2023-09-12T00:00:00+00:00
Planned Dates: Start Date 2017-06-12T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof John Hardy
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