Using visual dysfunction to understand dementia in Parkinson’s disease (360G-Wellcome-205167_Z_16_Z)
Dementia affects half of patients with Parkinson’s disease (PD) but there are no robust measures to predict who is at highest risk. Visual hallucinations are highly distressing to patients and carers but are poorly understood. This Fellowship will use visuo-perceptual dysfunction to predict dementia and understand hallucinations in PD. I have developed a novel test using skewed images to detect visuo-perceptual deficits in Parkinson’s patients. I have also developed a web-based platform to enable this and other visual tests to be accessed by large numbers of patients with PD. In this proposal I will use visual perceptual tests combined with neuroimaging over time to determine the sequence of visuo-perceptual deficits in PD. I will relate these to changes in hallucinations. I will use my web-based platform to identify clinical and genetic associations with visual deficits and determine their role in predicting dementia in PD. Goals 1. Characterise changes in visuo-perception as PD progresses and correlate deficits with brain atrophy. 2. Relate MRI structural connectivity changes with disease progression. 3. Examine clinical and genetic associations of visual dysfunction in PD. 4. Test whether transcranial stimulation can improve visuo-perceptual function in PD. 5. Determine how visual hallucinations become distressing as PD advances.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
| Region | London |
| Award Date | 2016-12-06T00:00:00+00:00 |
| Sponsor(s) | Prof John Hardy |
| Internal ID | 205167/Z/16/Z |
| Planned Dates: End Date | 2023-09-11T00:00:00+00:00 |
| Planned Dates: Start Date | 2017-06-12T00:00:00+00:00 |
| Amount Awarded | 1223282 |
| Financial Year | 2016/17 |
| Lead Applicant | Prof Rimona Sharon Weil |
| Grant Programme: Title | Clinical Research Career Development Fellowship - Stage 2 |
| Applicant Surname | Weil |
| Approval Committee | Clinical Interview Committee |
| Recipient Org: Country | United Kingdom |
| Recipient Org: City | London |
| Has the grant transferred? | No |
| Research conducted at multiple locations? | No |
| Total amount including partnership funding | 1223282 |