Obesity: Exploiting Genomes for Novel Insights (360G-Wellcome-205187_Z_16_Z)
What are the mechanisms by which genes influence an individuals propensity to obesity. I study animal models to find answers to that question. I will study the link between genes and obesity in two complementary research streams. Firstly, I will build on my recent discovery of an obesity-associated POMC mutation in animal models which disrupts hypothalamic leptin-melanocortin signalling. Deep phenotyping of eating behaviour and physiology in the absence and presence of a synthetic MC4R agonist with the goal of defining the contribution of POMC-derived peptides to energy homeostasis. Secondly, I will use genome-wide association studies in animals to find further genetic determinants of obesity. Their relevance to humans will be tested in large patient cohorts with both rare, severe obesity and common obesity, and putative obesity loci studied in relevant cell models. Preliminary data has shown this approach is successful.
£415,141 06 Dec 2016
Where is this data from?
This data was originally published by The Wellcome Trust. If you need to report a problem in the data please contact The Wellcome Trust directly, see their GrantNav publisher page for more information.
| Amount Awarded | 415141 |
| Applicant Surname | Raffan |
| Approval Committee | Clinical Interview Committee |
| Award Date | 2016-12-06T00:00:00+00:00 |
| Financial Year | 2016/17 |
| Grant Programme: Title | Clinical Research Career Development Fellowship |
| Internal ID | 205187/Z/16/Z |
| Lead Applicant | Dr Eleanor Raffan |
| Planned Dates: End Date | 2021-01-01T00:00:00+00:00 |
| Planned Dates: Start Date | 2017-04-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |
| Sponsor(s) | Prof Sir Stephen O'Rahilly |
