An advanced cryoEM instrument for the University of Cambridge (360G-Wellcome-206171_Z_17_Z)

£3,000,000

We seek support to consolidate an advanced electron cryo-microscopy (cryo-EM) facility dedicated to structural studies of biological macromolecular assemblies. The facility would provide a revolutionary new tool to the large structural biology community in the University that would enable acquisition of critical data in support of a wide and diverse range of projects tackling fundamental problems in molecular biology relevant to human health. Currently, the named applicants primarily use X-ray crystallography to study large assemblies, but many of these samples cannot be readily crystallised. The recent development of a new generation of direct electron detectors, together with sophisticated data-processing software, has dramatically improved cryo-EM analysis, which now achieves routinely sub-nanometer resolution. Until recently, researchers in the university did not have access to cryoEM, but this has changed with the recent Wellcome Trust award to purchase a cryo-EM instrument for sample screening and intermediate resolution structure determination. We are building on this support, to develop the second phase of our strategy and seek funding for an advanced microscope capable of high resolution structure determination to complement and extend our existing instrumentations.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 3000000
Applicant Surname Luisi
Approval Committee Cryo-EM Advisory Committee
Award Date 2016-12-07T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Cryo-Electron Microscopy Equipment grant
Internal ID 206171/Z/17/Z
Lead Applicant Prof Ben Luisi
Other Applicant(s) Dr Judy Hirst, Dr Simone Weyand, Prof Alan Warren, Prof Luca Pellegrini, Prof Melinda Duer, Prof Peter St George-Hyslop, Prof Randy Read, Prof Sir John Walker, Prof Sir Tom Blundell
Partnership Value 3000000
Planned Dates: End Date 2022-06-12T00:00:00+00:00
Planned Dates: Start Date 2017-06-12T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England