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An advanced cryoEM instrument for the University of Cambridge (360G-Wellcome-206171_Z_17_Z)

<p>We seek support to consolidate an advanced electron cryo-microscopy (cryo-EM) facility dedicated to structural studies of biological macromolecular assemblies. The facility would provide a revolutionary new tool to the large structural biology community in the University that would enable acquisition of critical data in support of a wide and diverse range of projects tackling fundamental problems in molecular biology relevant to human health. Currently, the named applicants primarily use X-ray crystallography to study large assemblies, but many of these samples cannot be readily crystallised. The recent development of a new generation of direct electron detectors, together with sophisticated data-processing software, has dramatically improved cryo-EM analysis, which now achieves routinely sub-nanometer resolution. Until recently, researchers in the university did not have access to cryoEM, but this has changed with the recent Wellcome Trust award to purchase a cryo-EM instrument&nbsp;for sample screening and intermediate resolution structure determination. We are building on this support, to develop the second phase of our strategy and seek funding for an&nbsp;advanced microscope capable of&nbsp;high resolution structure determination to complement and extend our existing instrumentations.</p>

£3,000,000

07 Dec 2016

Grant details
Amount Awarded 3000000
Applicant Surname Luisi
Approval Committee Cryo-EM Advisory Committee
Award Date 2016-12-07T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Cryo-Electron Microscopy Equipment grant
Internal ID 206171/Z/17/Z
Lead Applicant Prof Ben Luisi
Other Applicant(s) Prof Alan Warren, Dr Simone Weyand, Prof Luca Pellegrini, Prof Melinda Duer, Prof Randy Read, Dr Judy Hirst, Prof Peter St George-Hyslop, Prof Sir John Walker, Prof Sir Tom Blundell
Planned Dates: End Date 2022-06-12T00:00:00+00:00
Planned Dates: Start Date 2017-06-12T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
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