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Schwann cell-axonal communication during axonal degeneration and regrowth (360G-Wellcome-206634_Z_17_Z)

Myelinating and non-myelinating Schwann cells are reprogrammed after nerve injury into repair Schwann cells, specialized for maintaining survival of injured neurons and supporting axonal regeneration. This process is regulated by Schwann cell-intrinsic signals, such as the transcription factor c-Jun, however few other candidates have been identified. It is, currently, unknown how Schwann cell reprogramming is initiated, but unidentified extrinsic signals from injured axons are likely candidates. I aim to delineate the spatial and temporal regulation of Schwann cell-intrinsic downstream signals in real-time and define their role in repair Schwann cell function and axonal regeneration. Secondly, I aim to test the hypothesis that axon-derived signals initiate Schwann cell reprogramming during nerve injury. I will use cell culture, in vivo mouse models and a live and dynamic zebrafish larval model of nerve injury. This study will be the first to investigate how axon-intrinsic mechanisms of nervous system injury interplay with glial cell molecular responses to nerve damage, in real-time. Using cutting edge techniques in two species, this project will significantly advance our understanding of Schwann cell-axonal biology and tissue repair. Excitingly, this research may identify new potential therapeutic targets to improve poorly regenerating human nerves and treat patients with neuropathies.


25 May 2017

Grant details
Amount Awarded 426876
Applicant Surname Arthur-Farraj
Approval Committee Clinical Interview Committee
Award Date 2017-05-25T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Clinical Research Career Development Fellowship
Internal ID 206634/Z/17/Z
Lead Applicant Dr Peter Arthur-Farraj
Planned Dates: End Date 2021-09-11T00:00:00+00:00
Planned Dates: Start Date 2017-09-11T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Michael Coleman
additional_data_added True
id_and_name ["University of Cambridge", "360G-Wellcome-ORG:University-of-Cambridge"]
Additional data added by GrantNav