Impact of chronic endometritis on endometrial stem cell population (360G-Wellcome-206902_Z_17_Z)
Recurrent miscarriage (RM) has been linked to stem cell deficiency, heightened cellular senescence and impaired decidualization (differentiation) of the endometrium, although the cause of stem cell deficiency is unknown. I hypothesize that low-grade endometritis, defined by the presence of CD138-positive plasma cells in the superficial endometrium, may cause endometrial mesenchymal stem cell (eMSC) depletion. To test this hypothesis, I will establish clonogenic assay from endometrial stromal cells purified from CD138-positive and -negative mid-luteal endometrial biopsies from RM patients. Furthermore, the responsiveness of clonal endometrial MSCs to decidualization signals will be assessed.
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Grant Details
| Amount Awarded |
0
|
| Applicant Surname | Hong |
| Approval Committee | Internal Decision Panel |
| Award Date | 2017-04-27T00:00:00+00:00 |
| Financial Year | 2016/17 |
| Grant Programme: Title | Vacation Scholarships |
| Internal ID | 206902/Z/17/Z |
| Lead Applicant | Ms Elizabeth Hong |
| Partnership Value | 0 |
| Planned Dates: End Date | 2017-08-25T00:00:00+00:00 |
| Planned Dates: Start Date | 2017-06-26T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | West Midlands |