Optimisation of novel small molecule antivirals. (360G-Wellcome-207333_Z_17_Z)

£0

Respiratory syncytial virus (RSV) causes severe bronchiolitis in susceptible populations, particularly babies and the elderly and is responsible for one-third of acute lower respiratory tract infection related deaths in infants less than one year of age. There is currently no vaccine. This project will use open source cheminformatics and bioinformatics hosted at Elixir UK, together with HEp2 and HepG2 model cell assays of a set of novel inhibitors that have been found to be effective against the virus to improve their solubility, toxicity and distribution profile to lung tissue and stability in the body. Inhibition of host protein DDX3 that the virus is obliged to use prevents the expression of viral proteins and reduces severity of RSV in our pre-clinical studies. Closely structurally related inhibitors are active against very serious infections including dengue and West Nile virus. They have potential to become broad-spectrum antivirals and hence of relevance to hospitals in the UK as well as to global health. We will: 1. Identify antiviral - protein transporter partnerships. 2. Identify and acquire commercial inhibitors of these transporters. 3. Use these inhibitors to test the hypothesis that the antivirals are transported by these proteins in suitable liver and lung cell models.

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Grant Details

Amount Awarded 0
Applicant Surname Clayton
Approval Committee Internal Decision Panel
Award Date 2017-04-27T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Vacation Scholarships
Internal ID 207333/Z/17/Z
Lead Applicant Mr Matthew Clayton
Partnership Value 0
Planned Dates: End Date 2017-09-16T00:00:00+00:00
Planned Dates: Start Date 2017-07-17T00:00:00+00:00
Recipient Org: Country United Kingdom
Region West Midlands