The retention of memory and creation of knowledge (360G-Wellcome-207481_Z_17_Z)
Memories are often formed automatically, selectively retained and then some information becomes incorporated into the networks of knowledge that each of us possess. A key challenge is to identify the neural mechanisms responsible for the selective retention of recent hippocampal-dependent memory traces and those mediating the incorporation of this information into existing knowledge networks in the neocortex. Phase 1 concerns selectivity: Guided by predictions of the synaptic-tagging-and-capture hypothesis of protein synthesis-dependent memory consolidation, we would use a novel everyday-memory task to follow up our observations that certain parameters of learning, including peri-event novelty, enhance memory retention. Experiments using genetically modified animals that involve neurotransmitter imaging and endoscopic Ca2+ imaging would explore the potentially critical role of a neural circuit from the locus coeruleus to the hippocampus in selective retention. Phase 2 addresses knowledge assimilation: This work would be conducted in the context of the new schema theory of semantic-like memory that presupposes that prior knowledge guides memory updating. It would follow up our original experiments on schema learning, introduce a new method for doing such experiments, explore endoscopic imaging in both hippocampus and neocortex, and the network contributions of distinct neocortical regions using a disconnection approach.
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Grant Details
Amount Awarded | 1660214 |
Applicant Surname | Morris |
Approval Committee | Science Interview Panel |
Award Date | 2017-07-11T00:00:00+00:00 |
Financial Year | 2016/17 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 207481/Z/17/Z |
Lead Applicant | Prof Richard Morris |
Partnership Value | 1660214 |
Planned Dates: End Date | 2023-08-31T00:00:00+00:00 |
Planned Dates: Start Date | 2017-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Scotland |