The retention of memory and creation of knowledge (360G-Wellcome-207481_Z_17_Z)

£1,660,214

Memories are often formed automatically, selectively retained and then some information becomes incorporated into the networks of knowledge that each of us possess. A key challenge is to identify the neural mechanisms responsible for the selective retention of recent hippocampal-dependent memory traces and those mediating the incorporation of this information into existing knowledge networks in the neocortex. Phase 1 concerns selectivity: Guided by predictions of the synaptic-tagging-and-capture hypothesis of protein synthesis-dependent memory consolidation, we would use a novel everyday-memory task to follow up our observations that certain parameters of learning, including peri-event novelty, enhance memory retention. Experiments using genetically modified animals that involve neurotransmitter imaging and endoscopic Ca2+ imaging would explore the potentially critical role of a neural circuit from the locus coeruleus to the hippocampus in selective retention. Phase 2 addresses knowledge assimilation: This work would be conducted in the context of the new schema theory of semantic-like memory that presupposes that prior knowledge guides memory updating. It would follow up our original experiments on schema learning, introduce a new method for doing such experiments, explore endoscopic imaging in both hippocampus and neocortex, and the network contributions of distinct neocortical regions using a disconnection approach.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 1660214
Applicant Surname Morris
Approval Committee Science Interview Panel
Award Date 2017-07-11T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Investigator Award in Science
Internal ID 207481/Z/17/Z
Lead Applicant Prof Richard Morris
Partnership Value 1660214
Planned Dates: End Date 2023-08-31T00:00:00+00:00
Planned Dates: Start Date 2017-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland