Influence of Sleep on Human Brain Structure (360G-Wellcome-209192_Z_17_Z)

£250,000

Sleep is essential to brain functioning and its loss greatly impairs cognition, yet the brain mechanisms underlying the cognitive benefits of sleep remain largely unclear. During sleep, the brain’s functional networks break down, with different brain regions showing decoupled activities. I hypothesize that this decoupling of brain regions will facilitate the remodeling and optimization of brain structural networks, leading to improved brain functioning and cognitive performances after sleep. I will test my hypothesis in human participants by combining measures of brain structure, function, cognition, with brain stimulation during sleep. First, I will study how the structure of inter-regional connections change after sleep, whether these changes improve the network properties, and how these changes are reflected in the function of inter-regional communications. Then, I will study how the post-sleep changes in brain function correlate with brain activity in sleep, and whether these functional changes can be modulated by brain stimulation during sleep. Last, I will study how the post-sleep changes in brain structure differ across different inter-regional connections, and whether these structural changes can predict the selective influences of sleep on different cognitive performances. Overall, this project aims to explore how sleep benefits cognition by improving brain structure for higher functionality.

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Grant Details

Amount Awarded 250000
Applicant Surname Song
Approval Committee Basic Science Interview Committee
Award Date 2017-11-08T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Sir Henry Wellcome Postdoctoral Fellowship
Internal ID 209192/Z/17/Z
Lead Applicant Dr Chen Song
Partnership Value 250000
Planned Dates: End Date 2024-01-01T00:00:00+00:00
Planned Dates: Start Date 2018-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Wales
Sponsor(s) Prof Petroc Sumner