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The Role Of Small-molecule Dietary And Non-dietary Antioxidants In Predicting And Preventing Respiratory Disease (360G-Wellcome-209207_Z_17_Z)

<p>Respiratory diseases caused by smoking and pollution are increasing in prevalence across all continents. At present, there are no simple blood tests for predicting those at highest risk and few molecular targets for primary prevention. This work programme will use pre-collected data to answer the following: do antioxidant molecules found in blood (bilirubin, uric acid, alpha-tocopherol, ascorbic acid and beta-carotene) have any role in the prevention or prediction of respiratory disease? Firstly, I will use conventional risk factors and incident cases of lung cancer recorded for UK Biobank participants to build a risk prediction model. I will then add various combinations of baseline measures of bilirubin, uric acid, their associated genotypes, and respiratory function. The added value of these variables will be assessed using reclassification measures and net benefit analysis. Secondly, I will develop an economic model using UK Biobank and other data sources to evaluate the&nbsp;cost-effectiveness of the risk model combined with different screening strategies (e.g. chest scans).&nbsp;Finally, I will use the new genotype&nbsp;data for the 500,000 participants of UK Biobank to perform a series of instrumental variable analyses (Mendelian randomization) and examine&nbsp;causal relationships between lifelong variation in small-molecule antioxidant exposure and adult respiratory function.</p>

£284,626

08 Nov 2017

Grant details
Amount Awarded 284626
Applicant Surname Horsfall
Approval Committee Basic Science Interview Committee
Award Date 2017-11-08T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Career Re-Entry Fellowship
Internal ID 209207/Z/17/Z
Lead Applicant Dr Laura Horsfall
Planned Dates: End Date 2022-04-01T00:00:00+00:00
Planned Dates: Start Date 2018-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Irwin Nazareth
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