Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

Adult-Neurogenesis and Network Remodeling on Zebrafish Telencephalon (360G-Wellcome-210219_Z_18_Z)

<p>Zebrafish exhibits adult neurogenesis throughout their brain, conferring them the amazing ability to regenerate damaged brain regions. The study of network remodeling by adult neurogenesis involves complex relationships between newly-added neurons, preexisting networks, and neuronal activity. This proposal combines my expertise on adult-neurogenesis and information processing, the zebrafish capability to perform network remodeling, and the available genetic tools to label different zebrafish neuronal types, as: progenitors, glutammatergic and GABAergic neurons. By combining these transgenic fishes with BrdU tracing, molecular marker detection and electrophysiology, we will able to perform a rigorous and elegant characterization of the different neuronal repertoire contributed by adult neurogenesis to telencephalic pallial networks. Furthermore, the impact of cognitive function on network remodeling will be tested by <em>in vivo </em>two-photon Ca<sup>2+</sup> imaging on different cohorts of new-neurons.</p> <p>This project will be the seed for further research on functional neuronal regeneration and <em>de novo</em> wiring of pallial regions, assessed by the physiological and behavioral recovering of lesioned brain.</p> <p>&nbsp;</p>

£96,037

04 Dec 2017

Grant details
Amount Awarded 96037
Applicant Surname Mongiat
Approval Committee Science Seeds Advisory Panel
Award Date 2017-12-04T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Seed Award in Science
Internal ID 210219/Z/18/Z
Lead Applicant Dr Lucas Mongiat
Planned Dates: End Date 2020-05-22T00:00:00+00:00
Planned Dates: Start Date 2018-03-01T00:00:00+00:00
Recipient Org: Country Argentina
Region International
Additional data added by GrantNav