Adult-Neurogenesis and Network Remodeling on Zebrafish Telencephalon (360G-Wellcome-210219_Z_18_Z)

<p>Zebrafish exhibits adult neurogenesis throughout their brain, conferring them the amazing ability to regenerate damaged brain regions. The study of network remodeling by adult neurogenesis involves complex relationships between newly-added neurons, preexisting networks, and neuronal activity. This proposal combines my expertise on adult-neurogenesis and information processing, the zebrafish capability to perform network remodeling, and the available genetic tools to label different zebrafish neuronal types, as: progenitors, glutammatergic and GABAergic neurons. By combining these transgenic fishes with BrdU tracing, molecular marker detection and electrophysiology, we will able to perform a rigorous and elegant characterization of the different neuronal repertoire contributed by adult neurogenesis to telencephalic pallial networks. Furthermore, the impact of cognitive function on network remodeling will be tested by <em>in vivo </em>two-photon Ca²⁺ imaging on different cohorts of new-neurons.</p> <p>This project will be the seed for further research on functional neuronal regeneration and <em>de novo</em> wiring of pallial regions, assessed by the physiological and behavioral recovering of lesioned brain.</p> <p>&nbsp;</p>

£96,037

04 Dec 2017