Adult-Neurogenesis and Network Remodeling on Zebrafish Telencephalon (360G-Wellcome-210219_Z_18_Z)

Zebrafish exhibits adult neurogenesis throughout their brain, conferring them the amazing ability to regenerate damaged brain regions. The study of network remodeling by adult neurogenesis involves complex relationships between newly- added neurons, preexisting networks, and neuronal activity. This proposal combines my expertise on adult-neurogenesis and information processing, the zebrafish capability to perform network remodeling, and the available genetic tools to label different zebrafish neuronal types, as: progenitors, glutammatergic and GABAergic neurons. By combining these transgenic fishes with BrdU tracing, molecular marker detection and electrophysiology, we will able to perform a rigorous and elegant characterization of the different neuronal repertoire contributed by adult neurogenesis to telencephalic pallial networks. Furthermore, the impact of cognitive function on network remodeling will be tested by in vivo two-photon Ca2+ imaging on different cohorts of new- neurons. This project will be the seed for further research on functional neuronal regeneration and de novo wiring of pallial regions, assessed by the physiological and behavioral recovering of lesioned brain.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 96036.65
Applicant Surname Mongiat
Approval Committee Science Seeds Advisory Panel
Award Date 2017-12-04T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Seed Award in Science
Has the grant transferred? No
Internal ID 210219/Z/18/Z
Lead Applicant Dr Lucas A Mongiat
Planned Dates: End Date 2020-05-31T00:00:00+00:00
Planned Dates: Start Date 2018-03-01T00:00:00+00:00
Recipient Org: City Buenos Aires
Recipient Org: Country Argentina
Region International
Research conducted at multiple locations? No
Total amount including partnership funding 96036.65