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East London Genes & Health: human knockouts in a population genomic medicine cohort of British-South Asians (360G-Wellcome-210561_Z_18_Z)

East London Genes & Health is a long term programme for population genomic medicine research in British-South Asian adults. Unique features include high rates of health deprivation, especially diabetes, cardiovascular disease and mental health; high rates of consanguinity (including human knockouts, rare predicted loss of function variants occurring as homozygotes); local excellence in e-health record access/analysis; and recall for further research by genotype/phenotype. In this proposal we wish to continue and expand successful East London Genes & Health recruitment and commence a new site Bradford Genes & Health - to reach 100,000 volunteers; add value to the Genes & Health resource through SNP array genotyping all samples; and by sequencing and analysing consanguineous individuals. This will then enable us as a collaborative team to ask detailed research questions about adult-human knockouts. Specifically we will perform population based analyses of naturally occurring adult-human knockouts to better understand their population genetics, and (with Deciphering Developmental Disorders) recessive disease; contribute to and establish The Human Knockout Project, a worldwide database of population-based studies of human knockouts; perform blood -omics to study major perturbations of biological systems including downstream networks; and deeply study individuals with knockouts and other variants in reported Mendelian disease genes.

£4,142,778

10 Apr 2018

Grant details
Amount Awarded 4142778
Applicant Surname van Heel
Approval Committee Science Interview Panel
Award Date 2018-04-10T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Collaborative Award in Science
Internal ID 210561/Z/18/Z
Lead Applicant Prof David van Heel
Other Applicant(s) Prof Christopher Griffiths, Prof Mark McCarthy, Dr Daniel MacArthur, Prof John Wright, Dr Hilary Martin, Dr Matthew Hurles, Prof Richard Trembath
Planned Dates: End Date 2023-10-01T00:00:00+00:00
Planned Dates: Start Date 2018-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
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