East London Genes & Health: human knockouts in a population genomic medicine cohort of British-South Asians (360G-Wellcome-210561_Z_18_Z)
East London Genes & Health is a long term programme for population genomic medicine research in British-South Asian adults. Unique features include high rates of health deprivation, especially diabetes, cardiovascular disease and mental health; high rates of consanguinity (including human knockouts, rare predicted loss of function variants occurring as homozygotes); local excellence in e-health record access/analysis; and recall for further research by genotype/phenotype. In this proposal we wish to continue and expand successful East London Genes & Health recruitment and commence a new site Bradford Genes & Health - to reach 100,000 volunteers; add value to the Genes & Health resource through SNP array genotyping all samples; and by sequencing and analysing consanguineous individuals. This will then enable us as a collaborative team to ask detailed research questions about adult-human knockouts. Specifically we will perform population based analyses of naturally occurring adult-human knockouts to better understand their population genetics, and (with Deciphering Developmental Disorders) recessive disease; contribute to and establish The Human Knockout Project, a worldwide database of population-based studies of human knockouts; perform blood -omics to study major perturbations of biological systems including downstream networks; and deeply study individuals with knockouts and other variants in reported Mendelian disease genes.
£4,142,778 10 Apr 2018
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Amount Awarded | 4142778 |
Applicant Surname | van Heel |
Approval Committee | Science Interview Panel |
Award Date | 2018-04-10T00:00:00+00:00 |
Financial Year | 2017/18 |
Grant Programme: Title | Collaborative Award in Science |
Internal ID | 210561/Z/18/Z |
Lead Applicant | Prof David van Heel |
Other Applicant(s) | Prof Christopher Griffiths, Prof Mark McCarthy, Dr Daniel MacArthur, Prof John Wright, Dr Hilary Martin, Dr Matthew Hurles, Prof Richard Trembath |
Planned Dates: End Date | 2023-10-01T00:00:00+00:00 |
Planned Dates: Start Date | 2018-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |