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An Extended Pilot for the Human Cell Atlas: Adult tissues, human development and inflammation-mediated pathologies (360G-Wellcome-211276_Z_18_Z)

<p>The Human Cell Atlas (HCA) is an international, collaborative effort that &ldquo;&hellip;aims to define all human cell types in terms of their distinctive patterns of gene expression, physiological states, developmental trajectories, and location&rdquo;.</p> <p>&nbsp;</p> <p>Here, we will contribute directly to the first phase of the HCA by forming an &lsquo;extended pilot&rsquo; to implement UK infrastructure for large-scale, high quality human cell atlas experiments. We will generate a high-level atlas, with spatial resolution, for multiple adult human tissues along with matched data from human fetal material. We will then illustrate the power of a deep and focused investigation of a single tissue (skin) to produce highly-detailed data describing its cellular composition and spatial organisation. Finally, for selected tissues that have been profiled in adults and fetal material, we will analyse samples from immune-mediated disorders as a comparison with our reference data to gain deeper understanding of the pathological mechanisms. This will demonstrate the utility of the HCA as a &lsquo;healthy reference&rsquo; for comparison with disease.</p> <p>&nbsp;</p> <p>Throughout, we will generate profound biological insight from primary human cells and lay a foundation of technology development and optimisation with a set of hardened and scalable methods for single-cell RNA-sequencing, spatially-resolved gene expression, and tissue imaging.</p>

£3,878,823

30 Sep 2018

Grant details
Amount Awarded 3878823
Applicant Surname Teichmann
Approval Committee Internal Decision Panel
Award Date 2018-09-30T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Strategic Support: Science
Internal ID 211276/Z/18/Z
Lead Applicant Dr Sarah Teichmann
Planned Dates: End Date 2021-04-01T00:00:00+00:00
Planned Dates: Start Date 2018-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
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