Developing tissue-engineered dysplastic oral mucosa models to study the extracellular matrix (ECM) in oral squamous cell carcinoma (OSCC) progression (360G-Wellcome-211887_Z_18_Z)
Cancer progression is determined by the interaction between tumour cells, stromal cells (fibroblasts and leukocytes) and other components of the microenvironment such as the extracellular matrix (ECM). The ECM is predominantly deposited by dysplastic and cancer-associated fibroblasts (CAF) and play key roles in cancer progression. Although considerable evidence exists demonstrating a role for dysplastic fibroblasts and CAF in oral squamous cell carcinoma (OSCC), little is known about their influence on ECM: tumour interactions. This project aims to generate and begin to characterise novel tissue-engineered 3D constructs using dysplastic-derived ECM, as a native scaffold to accurately model tumour:ECM interactions in OSCC progression.
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Grant Details
| Amount Awarded |
0
|
| Applicant Surname | Guillen |
| Approval Committee | Internal Decision Panel |
| Award Date | 2018-05-31T00:00:00+00:00 |
| Financial Year | 2017/18 |
| Grant Programme: Title | Vacation Scholarships |
| Internal ID | 211887/Z/18/Z |
| Lead Applicant | Miss Jowi Guillen |
| Partnership Value | 0 |
| Planned Dates: End Date | 2018-09-08T00:00:00+00:00 |
| Planned Dates: Start Date | 2018-07-09T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Yorkshire and the Humber |