21st Century Treatments for the Sustainable Elimination of Leishmaniasis (360G-Wellcome-212346_Z_18_Z)

£10,044,444

The programme goal is to transform leishmaniasis treatment from the use of toxic, painful injectable antimonial therapies to a simple, orally acting and well tolerated treatment easy to use in resource poor settings. The strategy will rely on developing an oral combination of two co-administered drugs to maximise efficacy, reduce dose and duration of treatment, minimise side effects, and prevent or delay the emergence of drug resistance. DNDi, GlaxoSmithKline, the University of Dundee, Anacor, Pfizer, The Global Alliance for TB Drug Development, Takeda Pharmaceuticals and Celgene have built an unprecedented portfolio of candidates against Leishmania parasites. This pipeline is a strong basis for advancing towards oral leishmaniasis therapy(ies), to overcome attrition in development and identify one or more combination treatments for visceral leishmaniasis as the priority disease and also potentially for cutaneous leishmaniasis. This programme will evaluate 10 candidates aiming to select two orally-active New Chemical Entities (NCEs) ready for testing as a combination in Phase II studies in patients, maintaining a backup option of a combination of a single NCE with the existing oral drug, miltefosine. In the longer term, the programme aims to deliver new oral, high efficacy and affordable drug combinations for leishmaniasis.”

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Grant Details

Amount Awarded 10044444
Applicant Surname Mowbray
Approval Committee Science, Innovation and Translation Programme Advisory Group
Award Date 2018-09-30T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Innovations Priority Project
Internal ID 212346/Z/18/Z
Lead Applicant Dr Charles Mowbray
Other Applicant(s) Dr Fabiana Alves, Dr Jean-Yves Gillon, Dr Stephen Robinson
Partnership Value 10044444
Planned Dates: End Date 2022-03-24T00:00:00+00:00
Planned Dates: Start Date 2019-01-25T00:00:00+00:00
Recipient Org: Country Switzerland
Region International